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Since its inception in the mids, the General Practice Research Database GPRD has undergone many changes but remains the largest validated and most utilised primary care database in the UK. Its use in pharmacoepidemiology stretches back many years with now over original research papers. Administered by the Medicines and Healthcare products Regulatory Agency since , the last 5 years have seen a rebuild of the database processing system enhancing access to the data, and a concomitant push towards broadening the applications of the database.

New methodologies including real-world harm—benefit assessment, pharmacogenetic studies and pragmatic randomised controlled trials within the database are being implemented. A substantive and unique linkage program using a trusted third party has enabled access to secondary care data and disease-specific registry data as well as socio-economic data and death registration data. The utility of anonymised free text accessed in a safe and appropriate manner is being explored using simple and more complex techniques such as natural language processing.

A number of reviews throughout its history have described GPRD research in the area of pharmacoepidemiology, epidemiology, public health and clinical outcomes research [ Lawson et al. Few of these have addressed any aspects of organising and maintaining such a data set or the role of an organisation with whom the responsibility of managing such a resource lays. These issues are however critical in terms of providing a vehicle for undertaking clinical research, and are applicable to all primary care data sets available in the UK.

This review looks at some issues related to these questions as well as considering current research using GPRD. It also describes some of the areas of novel research being undertaken within or in collaboration with the GPRD organisation. The GPRD evolved from an early general practice information system. Free computing equipment was supplied in return for standardised data recording and provision of patient-level data into a central database to be used for health research [ Whalley and Mantgani, ].

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